Tab Application Banner
  • Users Online: 559
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Reader Login
Export selected to
Reference Manager
Medlars Format
RefWorks Format
BibTex Format
  Access statistics : Table of Contents
   2014| September  | Volume 9 | Issue 3  
    Online since July 11, 2016

  Archives   Previous Issue   Next Issue   Most popular articles   Most cited articles
Hide all abstracts  Show selected abstracts  Export selected to
  Viewed PDF Cited
Performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis in a prospective early arthritis cohort in Kerala, India
Vinod Ravindran, Ahlam Abdulaziz, Palli Valappil Bhargavan
September 2014, 9(3):107-111
Objectives: In this prospective study we evaluated (i) whether the 2010 ACR/EULAR criteria would include patients who were classified as early rheumatoid arthritis (RA) according to the 1987 ACR criteria, and (ii) outcome by classification of patients who were initially classified as undifferentiated arthritis (UA). Methods: Eligible cohort (all patients with at least one clinically swollen joint) consisted of 134 patients, of which 120 had clinical diagnosis of RA. All patients were classified using both 1987 and the 2010 criteria at the beginning of the study and 1 year later. Results: Out of 134 eligible patients 102 were classified as RA based on 1987 criteria. A total of 82 (80%) out of 102 patients were seropositive for RA, i.e. positive for either rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA). According to the 2010 criteria, 86 (84%) out of the 102 patients were classified as having RA. Among the 82 seropositive pa- tients, only 1 (1.21%) patient was classified as not having RA whereas, among 20 patients who had seronegative (both for RF and ACPA) RA, 15 (75%) patients were not classified as RA according to the 2010 criteria. Sensitivity and specificity of the 2010 criteria was 96.67% and 92.86%, respectively, compared with 85% and 85.71% by 1987 criteria. 25% of initial UA patients were reclassified as RA by the 2010 criteria at 1 year. Conclusions: The 2010 criteria did not identify a substantial proportion of seronegative RA classified by the 1987 criteria. Therefore due care must be taken when applying the new criteria to patients with arthritis who are seronegative.
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub] [CITATIONS]
  1,508 364 2
A look at the various ratios in medicine e risk ratio, odds ratio and likelihood ratio
Sourabh Dutta
September 2014, 9(3):136-140
This article focuses on 3 kinds of ratios commonly used in biostatistics and research: risk ratio, odds ratio and likelihood ratio. It clarifies the meaning of risk and odds and then delves into the respective ratios.
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub] [CITATIONS]
  1,421 386 2
Serum IL-6 level as a marker of disease activity in ankylosing spondylitis patients with pure axial involvement
Shefali Khanna Sharma, Shaheen Ahmad, Surender Kumar Sharma,
September 2014, 9(3):115-119
Background: The assessment of disease activity in patients with ankylosing spondylitis (AS) continues to be a challenging issue. The currently available markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) show poor correlation with clinical disease activity. Objectives: To compare serum IL-6 and hs-CRP levels between patients with AS with pure axial involvement and healthy controls; and to correlate them with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI). Methods: Sixty-two consecutive patients of AS with pure axial involvement satisfying the modified New York criteria and 60 age-matched healthy controls were recruited. In all patients, Bath indices were measured and fasting venous blood samples for serum IL-6 and hs-CRP levels were obtained. Comparison of median of serum IL-6 and hs-CRP levels was done between cases and healthy controls and levels also correlated with Bath indices by appropriate statistical methods. Results: The median serum IL-6 and hs-CRP levels were significantly higher in cases as compared to healthy controls (p ¼ 0.001). Serum IL-6 levels correlated significantly with BASDAI and BASFI (r ¼ 0.61, p ¼ 0.001 and r ¼ 0.27, p ¼ 0.032 respectively) but no correlation was found with BASMI (r ¼ -0.08, p ¼ 0.53).Serum hs-CRP did not correlate with Bath indices except BASMI (r ¼ 0.28, p ¼ 0.03). Conclusion: Serum IL-6 levels can be reliably used as an aid in monitoring of disease activity in AS patients with pure axial involvement.
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub] [CITATIONS]
  1,439 344 1
Classification of vasculitis: From historical controversies to present day pragmatic consensus
Richard A Watts
September 2014, 9(3):120-126
The classification of the systemic vasculitides has been controversial for several decades. However, over the past twenty years there have been several major developments, which means that there is pragmatic consensus regarding classification. These include the American College of Rheumatology criteria first published in 1990, and the Chapel Hill Consensus Conference definitions originally promulgated in 1994, but revised and extended in 2012. More recently the classical division of the ANCA vasculitides using clinical phenotype has come under scrutiny with evidence from epidemiological, genetic and outcome studies that perhaps these conditions should be classified on the basis of ANCA specificity into PR3-ANCA positive and MPO-ANCA positive groups. There remains, however, a major need for validated classification and diagnostic criteria, a need which hopefully the DCVAS project will address.
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,433 347 -
Rheumatology in Postgraduate curriculum
Rohini Handa
September 2014, 9(3):127-130
Full text not available  [PDF]  [Mobile Full text]  [EPub] [CITATIONS]
  1,402 226 6
Diagnosis of acute sarcoid arthritis (Lo€fgren's syndrome) in India, a country with high burden of tuberculosis
Amit Sharma, Anand N Malaviya
September 2014, 9(3):112-114
Objective: The present study was carried out to test if Visser et al's 2002 diagnostic criteria for acute sarcoid arthritis (Lo€fgren syndrome) are applicable in India, a country with high burden of tuberculosis. Methods: 30 consecutive patients classified as acute sarcoid arthritis according to Visser et al's criteria were included. They were screened for TB with standard Mantoux test, radiograph of chest and if found normal, contrast enhanced computerized tomography (CE-CT) of thorax. Results: 24 of 30 patients showed a negative Mantoux test as well as normal chest radio- graph and CE-CT. These patients were labeled as acute sarcoid arthritis. There were, 6 (20%) patients who had one or more features of TB by way of a positive Mantoux test and/or mediastinal lymphadenopathy with central necrosis, or asymmetrical hilar lymphade- nopathy. The latter patients were diagnosed as having Poncet's disease, a parainfectious arthritis associated with the presence of tuberculosis at a distant site way from muscu- loskeletal system. Therapeutic response to low-dose glucocorticoid, hydroxychloroquine and low-dose methotrexate produced dramatic results among those diagnosed with acute sarcoid arthritis. On the other hand, those diagnosed as having Poncet's disease were given standard anti-TB drugs with excellent response. Conclusion: In a country with high burden of TB like India Visser et al's clinical criteria for the diagnosis of acute sarcoid arthritis (Lo€fgren syndrome) may not be very specific; TB must be ruled out before diagnosing acute sarcoid arthritis (Lo€fgren syndrome).
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub] [CITATIONS]
  1,503 116 2
Rheumatoid arthritis 2010 ACR/EULAR classification criteria: How good are they for us?
Arun R Chogle
September 2014, 9(3):105-106
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,228 150 -
Rheumatology quiz
Vivek Arya, Varun Dhir
September 2014, 9(3):131-131
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,126 198 -
An unusual plaque on the nose
Mayur Bhobe, Swagata Tambe, Vijay Zawar, Hemangi Jerajani
September 2014, 9(3):141-142
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,133 92 -
Shortage of teaching faculty in rheumatology - Pragmatism necessary
Vinod Ravindran
September 2014, 9(3):159-160
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,053 154 -
Rheumatology reviews Julye-September 2014
Sukhbir Uppal
September 2014, 9(3):143-152
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,055 136 -
Management of refractory calcinosis e How far to go?
S Sham, S Rajeswari, R Ravichandran, N Thilagavathi
September 2014, 9(3):153-154
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,086 94 -
International publications of interest from India - (March 2014-May 2014)
Vivek Arya
September 2014, 9(3):132-135
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,083 94 -
Pioneers in Rheumatology William Heberden (Elder) (1710-1801)
VR Joshi, VB Poojary
September 2014, 9(3):160-160
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,065 94 -
Prostatic calcification in ochronosis
Jyoti Ranjan Parida, Durga Prasanna Misra, Pradeepta Sekhar Patro, Vikas Agarwal
September 2014, 9(3):155-156
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,056 85 -
Macrodactyly (Local gigantism)
Nilesh Nolkha, Puneet Kumar, Aarti Sharma, Meha Sharma
September 2014, 9(3):157-158
Full text not available  [PDF]  [Mobile Full text]  [EPub]
  1,051 85 -