Advanced Search
Users Online: 562
Home
About us
Editorial board
Ahead of print
Current issue
Search
Archives
Submit article
Instructions
Subscribe
Contacts
Reader Login
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Access statistics : Table of Contents
2010| March | Volume 5 | Issue 1
Online since
July 26, 2016
Archives
Previous Issue
Next Issue
Most popular articles
Most cited articles
Show all abstracts
Show selected abstracts
Export selected to
Viewed
PDF
Cited
ORIGINAL ARTICLES
Practising computer-aided objectified outcome-driven targeted treatment of rheumatoid arthritis in a resource constrained country: results from a single rheumatology clinic
AN Malaviya, D Agarwal, A Sharma, SB Gogia, Q Zaheer
March 2010, 5(1):3-10
Aims & Objectives:
The aim of the study was to test the feasibility of carrying out objectified assessment at each patient visit in a busy rheumatology clinic using a dedicated rheumatology software, adjusting the treatment accord- ingly to achieve predetermined outcome target of disease activity. The objective was to assess the results of tar- geted treatment to see if this method of RA treatment achieved better results than those by routine-care treatment that the patients received in the immediate past before coming to this clinic.
Patients and Methods:
RA patients presenting from 1-7-07 to 30-6-09 were included. Specialized rheumatology software (Medic-Aid Rheumatology®) was used for data recording, disease assessment and prescription writing. Details of past-health care providers, the type of treatment taken, method used for measuring treatment outcome were recorded at the first clinic visit. A pre-planned treatment protocol was used, guided by the DAS28 or CDAI values. The treatment response was statistically compared with the disease activity status at the first visit.
Results:
Study included 215 patients; 16% were having low disease activity or were in remission at the first presen- tation. Sixteen patients (7.4%) dropped out before adequate follow-up. The mean follow-up was for 37 (±12) weeks. Among 199 remaining patients, 83.4% had low disease activity or were in remission at the last follow-up visit. This difference was statistically highly significant.
Conclusion:
Using dedicated rheumatology software, it was feasible to carry out objectified assessment of the disease activity and functional status in every RA patient in real-time at each follow-up visit in a routine OPD setting. Objectified computer-aided assessment and outcome-driven targeted treatment with standard DMARDs achieved low disease activity/remission in a vast majority of patients. This could be a practical and highly effective treatment strategy for patients with RA in a resource-constrained country like ours.
[ABSTRACT]
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,585
125
-
REVIEW ARTICLES
Pregnancy and rheumatic disorders
Susheel Kumar, Vanita Suri, Ajay Wanchu
March 2010, 5(1):35-41
Autoimmune rheumatic diseases commonly affect young women with child-bearing potential. It is important to know the impact of these diseases on pregnancy, and conversely the effect of pregnancy on these diseases, which may have important implications for mothers and neonates. Majority of studies suggest that pregnancy aggravates sys- temic lupus erythematosus (SLE) disease activity while ameliorating the symptoms of rheumatoid arthritis (RA). This contrasting finding between RA and SLE in pregnancy is postulated to be due to the differences in autoimmune response. There is a raised Th2 type response during pregnancy in comparison to the non-pregnant state, leading to the over expression of Th2 cytokines, such as IL-4 and IL-10. These cytokines are believed to increase the autoantibody response in SLE but to be immunosuppressive in RA. Studies suggest that patients of systemic scle- rosis and mixed connective tissue disorder (MCTD) also have worsening of their underlying disorder while paucity of data precludes any solid conclusion regarding disease activity in patients of Sjogren's syndrome. Pregnancies in SLE, RA, systemic sclerosis (SSc) and MCTD patients are associated with a greater risk of relatively poor foetal out- come than in the general population, especially with increased disease activity before conception and early in preg- nancy. This review provides an update regarding the effect of pregnancy on autoimmune rheumatic disorders and vice-versa.
[ABSTRACT]
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,507
142
-
ORIGINAL ARTICLES
Relating bone marrow oedema to hs-CRP in knee osteoarthritis
H Bassiouni, K Zaki, M Elshorbagi, A Mustapha, R Tantawi, H Ali, S Metyas, DG Arkfeld
March 2010, 5(1):11-15
Objective:
To study the correlation between bone marrow oedema (BME) on knee magnetic resonance imaging (MRI) and plasma high sensitive-CRP (hs-CRP) levels in patients with symptomatic osteoarthritis (OA) of the knee.
Methods:
Thirty patients with symptomatic OA of the knee were included and stratified into three equal groups con- sisting of normal alignment, varus or valgus misalignment of symptomatic knee. Radiographic scoring using Kellgren-Lawrence grading (K-L grade) was performed and an MRI of the knee taken. Intensity of pain was evalu- ated using a pain visual analogue scale (VAS) and the functional status determined by Lequesne functional index. In addition, hs-CRP was estimated in all patients and in 20 healthy controls.
Results:
BME was present in 14 patients (46%) with OA and in none of the controls. Patients with BME had signifi- cantly longer disease duration, a higher lequesne score, suggesting greater functional impairment and more advanced radiological changes. A significantly higher number of patients (12/30, 40%) had an elevated hs-CRP than healthy controls (2/20, 10%,
P
= 0.02). There was, however, no association between hs-CRP and BME. Patients with varus and valgus deformities harboured BME on the medial and lateral tibiofemoral compartments, respectively.
Conclusion:
BME is a feature of advanced OA of the knee and is associated with radiographic progression, a greater functional impairment and longer disease duration. It is, however, not associated with raised hs-CRP levels.
[ABSTRACT]
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,512
96
-
CORRESPONDENCE
Change in blood group in a patient with systemic lupus erythematosus
Anand N Malaviya
March 2010, 5(1):55-56
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,479
106
-
CONSENSUS STATEMENT
Indian Rheumatology Association consensus statement on the diagnosis and treatment of axial spondyloarthropathies
AN Malaviya, S Shankar, V Arya, V Dhir, V Agarwal, S Pandya, K Shanmuganandan, VP Chaturvedi, CJ Das
March 2010, 5(1):16-34
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,408
156
-
PG FORUM
Rheumatology Quiz
V Arya, V Dhir
March 2010, 5(1):45-45
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,307
167
-
PERSPECTIVE
Indian rheumatology in 2025-looking ahead in 2010
Rohini Handa
March 2010, 5(1):42-44
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,305
112
-
EDITORIAL
Objectified assessment for effective disease management in rheumatoid arthritis: a little known secret
S Shankar
March 2010, 5(1):1-2
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,270
104
-
CORRESPONDENCE
Poncet's disease
R Gopal, D Jeyakumari, S Girija
March 2010, 5(1):56-56
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,273
77
-
PG FORUM
What is your diagnosis? Leg ulcers in SLE
Tufale Ahmed Dass
March 2010, 5(1):46-48
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,221
121
-
International publications of interest from India (December 2009-February 2010)
V Arya
March 2010, 5(1):49-50
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,245
77
-
RHEUMSERVICE
Rheumservice: Hot rheumatology updates
Sukhbir Uppal
March 2010, 5(1):51-54
Full text not available
[PDF]
[Mobile Full text]
[EPub]
1,209
77
-
© Indian Journal of Rheumatology | Published by Wolters Kluwer -
Medknow
Sitemap
|
What's New
|
Feedback
|
Disclaimer
|
Privacy Notice
Online since 29
th
June, 2016