Indian Journal of Rheumatology

REVIEW ARTICLE
Year
: 2022  |  Volume : 17  |  Issue : 3  |  Page : 279--288

Anti-inflammatory effects of photobiomodulation in the management of osteoarthritis of the temporomandibular joint: A systematic review of animal studies


Virginia Bautista1, Sandeep Talluri1, Olga A Korczeniewska2, Dimitrios Michelogiannakis3, Junad Khan1 
1 Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA
2 Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Rutgers University, Newark, NJ, USA
3 Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA

Correspondence Address:
Dr. Junad Khan
Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, 625 Elmwood Ave, Box 683, Rochester, NY 14642
USA

Aim: There is a controversy in regards to the efficacy of photobiomodulation (PB) in the management of osteoarthritis (OA) of the temporomandibular joint (TMJ). The aim of this study was to assess if PB induces anti-inflammatory effects for the management of OA of the TMJ. Materials and Methods: The focused question was “Does PB induce anti-inflammatory effects for the management of OA of the TMJ?” Indexed database search was performed up to and including June 2020. Data regarding study design, study grouping, subjects, age, sex, OA induction method, outcome variables, and parameters regarding OA in TMJ were extracted. Results: A total of 47 articles were initially identified through indexed databases and 6 experimental animal studies were included in the present review. Overall the risk of bias was high in two studies and moderate in four studies. A variety of results were evaluated after histopathological, biochemical, and radiographic analysis. After PB, there was a reduction in the articular disc thickness in the anterior, middle, and posterior regions, inflammation in the retrodiscal tissues was significantly reduced, and there was reduced expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, glycosaminoglycans and caspase-3 on biochemical analysis of the TMJ. The condyle showed the absence of inflammation after low-level laser therapy, and there was also a reduction of inflammatory infiltrate in the TMJ. Conclusions: Within the limits of the present systematic review, it is concluded that PB is a potent therapeutic agent in the management of OA in TMJ.


How to cite this article:
Bautista V, Talluri S, Korczeniewska OA, Michelogiannakis D, Khan J. Anti-inflammatory effects of photobiomodulation in the management of osteoarthritis of the temporomandibular joint: A systematic review of animal studies.Indian J Rheumatol 2022;17:279-288


How to cite this URL:
Bautista V, Talluri S, Korczeniewska OA, Michelogiannakis D, Khan J. Anti-inflammatory effects of photobiomodulation in the management of osteoarthritis of the temporomandibular joint: A systematic review of animal studies. Indian J Rheumatol [serial online] 2022 [cited 2022 Dec 8 ];17:279-288
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=3;spage=279;epage=288;aulast=Bautista;type=0