Indian Journal of Rheumatology

CASE BASED REVIEW
Year
: 2021  |  Volume : 16  |  Issue : 3  |  Page : 353--358

Levamisole-Induced immune phenomenon and its various clinical manifestations in children: Two case reports along with review of literature


Anu Punnen Kocheril1, T Sathish Kumar1, Dharshini Sathishkumar2 
1 Department of Pediatrics, Pediatric Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. Anu Punnen Kocheril
Department of Pediatrics, Pediatric Rheumatology, Christian Medical College, Vellore - 632 004, Tamil Nadu
India

In literature, levamisole-induced immune manifestations were described mostly in association with its use in treatment of rheumatoid arthritis, malignancies, and recently, in relation to the use of illicit cocaine contaminated with levamisole among adults. Even though levamisole has been proven to be an inexpensive, safer, and effective drug with minimal side effects among children, it is not possible to undermine its potential side effects. The objective of this study was to describe levamisole-induced immune phenomenon and its manifestation in children. We describe two children with levamisole-induced immune phenomenon, leading to limb ischemia resulting in a gangrene and autoamputation of toes in the first child and an isolated microscopic hematuria in the second child along with a thorough review of available knowledge on this rare manifestation in children. Increased awareness of these rare but severe manifestations will remind clinicians to keep a high index of suspicion, its early recognizing, and withdrawal of offending drug before severe morbidity occurs in those children on levamisole.


How to cite this article:
Kocheril AP, Kumar T S, Sathishkumar D. Levamisole-Induced immune phenomenon and its various clinical manifestations in children: Two case reports along with review of literature.Indian J Rheumatol 2021;16:353-358


How to cite this URL:
Kocheril AP, Kumar T S, Sathishkumar D. Levamisole-Induced immune phenomenon and its various clinical manifestations in children: Two case reports along with review of literature. Indian J Rheumatol [serial online] 2021 [cited 2022 Jan 24 ];16:353-358
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=3;spage=353;epage=358;aulast=Kocheril;type=0