Indian Journal of Rheumatology

REVIEW ARTICLE
Year
: 2020  |  Volume : 15  |  Issue : 5  |  Page : 6--12

Current concepts in the pathogenesis of spondyloarthritis


Nibha Jain, Arumugam Moorthy 
 University Hospitals of Leicester NHS Trust, Leicester, UK

Correspondence Address:
Dr. Arumugam Moorthy
Consultant Rheumatologist, University Hospitals of Leicester NHS Trust, Leicester
UK

Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environmental factors including gut dysbiosis, mechanical stress, and transduction have been implicated in the pathogenesis. Recently, the interleukin (IL)-17/IL-23 pathway has been major focus due to it being therapeutic target. Herein, we reviewed various recent developments and current concepts in the pathogenesis of SpA.


How to cite this article:
Jain N, Moorthy A. Current concepts in the pathogenesis of spondyloarthritis.Indian J Rheumatol 2020;15:6-12


How to cite this URL:
Jain N, Moorthy A. Current concepts in the pathogenesis of spondyloarthritis. Indian J Rheumatol [serial online] 2020 [cited 2023 Jan 31 ];15:6-12
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=5;spage=6;epage=12;aulast=Jain;type=0