Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 9  |  Issue : 1  |  Page : 9--13

Lipid profile and its relationship with endothelial dysfunction and disease activity in patients of early Rheumatoid Arthritis


Omar Sharif Mullick1, Raja Bhattacharya1, Kuntal Bhattacharyya1, Rathindra Nath Sarkar1, Adwitiya Das2, Debajyoti Chakraborty1, Arijit Sarkar3, Abhisekh Das1 
1 Department of Medicine, Rheumatology Division, Calcutta Medical College, Kolkata, India
2 Department of Preventive and Social Medicine, All India Institute of Hygiene and Public Health, Kolkata, India
3 Department of Microbiology, GSL Medical College, Rajahmundry, AP, India

Correspondence Address:
Rathindra Nath Sarkar
Department of Medicine, Rheumatology Division, Calcutta Medical College, Kolkata
India

Background: Lipid profile derangements in patients with early rheumatoid arthritis (RA) have been described. These may predispose to premature atherosclerosis and early car- diovascular events. However data from India is sparse. Objective: To evaluate the serum lipid profiles in patients of early RA, and assess the inter- relationship between serum lipid profile, endothelial dysfunction, disease activity and inflammatory markers. Materials and Methods: 50 patients of early RA and 50 age and sex matched healthy controls were included in the study. Fasting lipid profiles and brachial artery flow mediated vaso- dilatation (FMV%) were estimated, along with other disease activity parameters in the RA group. Result: Early RA patients showed an atherogenic lipid profile characterized by an increase in the Total Cholesterol (TC) (180.12 ± 16.50 versus 141.30 ± 9.57; p value < 0.0001) and Low Density Lipoprotein-Cholesterol (LDL-C) (126.82 ± 17.49 versus 79.36 ± 10.04; p value < 0.0001) and a reduction in the High Density Lipoprotein-Cholesterol (HDL-C) (37.92 ± 3.85 versus 44.42 ± 4.38; p value < 0.0001) as compared with their age and sex matched healthy controls. Mean FMV% in early RA patients (3.87 ± 1.70) was less than the controls (8.7 ± 1.58). Patients of early RA showed an atherogenic lipid profile with high atherogenic ratios of TC/HDL and LDL/HDL thus suggesting that these patients are at higher risk of developing atherosclerosis. There was significant correlation between lipo- protein levels, disease activity, endothelial dysfunction and inflammation. Conclusion: Patients of early rheumatoid arthritis have an atherogenic lipid profile and impaired FMV%, which correlates with disease activity and inflammation.


How to cite this article:
Mullick OS, Bhattacharya R, Bhattacharyya K, Sarkar RN, Das A, Chakraborty D, Sarkar A, Das A. Lipid profile and its relationship with endothelial dysfunction and disease activity in patients of early Rheumatoid Arthritis .Indian J Rheumatol 2014;9:9-13


How to cite this URL:
Mullick OS, Bhattacharya R, Bhattacharyya K, Sarkar RN, Das A, Chakraborty D, Sarkar A, Das A. Lipid profile and its relationship with endothelial dysfunction and disease activity in patients of early Rheumatoid Arthritis . Indian J Rheumatol [serial online] 2014 [cited 2023 Jan 27 ];9:9-13
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2014;volume=9;issue=1;spage=9;epage=13;aulast=Mullick;type=0