Evaluation of efficacy of fluoxetine in the management of major depression and arthritis in patients of Rheumatoid Arthritis :Akhilesh Jain, Dharmendra Bhadauria, Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year : 2013 | Volume : 8 | Issue : 4 | Page : 165--169

Evaluation of efficacy of fluoxetine in the management of major depression and arthritis in patients of Rheumatoid Arthritis

Akhilesh Jain¹, Dharmendra Bhadauria²
¹ Department of Psychiatry, ESIC Model Hospital, Ajmer Road, Jaipur, Rajasthan, India
² Department of Nephrology, SGPGI, Lucknow, UP, India

Correspondence Address:
Akhilesh Jain
Department of Psychiatry, ESIC Model Hospital, Ajmer Road, Jaipur, Rajasthan
India

Background: Patients with chronic pain suffer significant reduction in physical, psycho- logical, and social well-being. Anxiety and depressive disorders occur in 20%e25% of pa- tients with Rheumatoid Arthritis (RA). Antidepressants are useful in the treatment of major depression, however the analgesic properties of this class of drugs is not clear. Objective: To study the association between RA and depression along with independent effect of fluoxetine on depression and arthritis. Method: One hundred women attending a rheumatology clinic with RA were included in the study along with controls. Hospital Anxiety Depression Rating Scale (HADS), Montgomerye Asberg Depression Rating Scale (MADRS) and Clinical Global Impression - Change Scale (CGI) were applied. Both the groups were treated with DMARD. RA with depression group also received fluoxetine. Results: Depression is significantly associated with RA; however severity of RA has no relationship with severity of depression. Treatment outcome was better and earlier with add on fluoxetine in the RA with depression group as compared to RA without depression. Conclusion: Treatment of associated depression may expedite the recovery of physical symptoms thus improving the quality of life of an individual with chronic painful conditions.

How to cite this article:
Jain A, Bhadauria D. Evaluation of efficacy of fluoxetine in the management of major depression and arthritis in patients of Rheumatoid Arthritis .Indian J Rheumatol 2013;8:165-169

How to cite this URL:
Jain A, Bhadauria D. Evaluation of efficacy of fluoxetine in the management of major depression and arthritis in patients of Rheumatoid Arthritis . Indian J Rheumatol [serial online] 2013 [cited 2023 Feb 5 ];8:165-169
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