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IMAGES IN RHEUMATOLOGY
Ahead of print publication  

Inverse Gottron's papules


 Department of Dermatology Venereology and Leprosy, Shri B M Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur, Karnataka, India

Date of Submission11-Apr-2022
Date of Acceptance27-May-2022
Date of Web Publication20-Sep-2022

Correspondence Address:
Arun C Inamadar,
Department of Dermatology Venereology and Leprosy, Shri B M Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur, Karnataka
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_77_22

  Abstract 


Keywords: Anti-MDA5 autoantibodies, dermatomyositis, Gottron's papules



How to cite this URL:
Inamadar AC, Adya KA, Janagond AB. Inverse Gottron's papules. Indian J Rheumatol [Epub ahead of print] [cited 2022 Oct 3]. Available from: https://www.indianjrheumatol.com/preprintarticle.asp?id=356483

A 40-year-old woman presented with facial edema and painful skin lesions involving the hands. On examination, heliotrope rash [Figure 1]a, hyperkeratotic ulcerated papules on the knuckles [Figure 1]b and erythematous, flat-to-raised keratotic lesions involving the palmar aspect of the interphalangeal joints [Figure 1]c were noted. A diagnosis of dermatomyositis (DM) was made with clinical features and raised muscle enzymes.
Figure 1: Clinical photograph showing heliotrope with periorbital edema (a) and Gottron's sign over dorsal aspect of hand (b), flat-to-raised lesions involving palmar aspect of the fingers in a distribution “inverse” of the classic Gottron's papules/sign (c, black arrow) and fingertip scars suggestive of healed ulcers (c, white arrow)

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Gottron's papules are pathognomonic of DM. Inverse Gottron's sign/papules [Figure 1]c, due to vasculopathy are a rare but specific cutaneous finding in DM, usually associated with digital ulceration, interstitial lung disease, and anti-MDA5 autoantibodies.[1],[2],[3]

Anti-MDA5-positive DM occurs in 7.2% of adults and 9.7% of children, respectively, in the Indian subcontinent. Cutaneous vasculopathic features such as cutaneous ulceration, and periorbital edema as seen in the index may indicate a worse poor prognosis in adults with anti-MDA-5 DM.[4]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Quinter SD, Chiu YE, Lyon VB, Holland KE, Ruggeri SY, Drolet BA. Inverse Gottron's papules: An unusual cutaneous manifestation of juvenile dermatomyositis. Pediatr Dermatol 2012;29:641-4.  Back to cited text no. 1
    
2.
Fiorentino D, Chung L, Zwerner J, Rosen A, Casciola-Rosen L. The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): A retrospective study. J Am Acad Dermatol 2011;65:25-34.  Back to cited text no. 2
    
3.
Jain S, Sharma A. Inverse Gottron's sign in anti-MDA5 antibody- associated dermatomyositis. Rheumatology (Oxford) 2020;59:10.  Back to cited text no. 3
    
4.
Dunga SK, Kavadichanda C, Gupta L, Naveen R, Agarwal V, Negi VS. Disease characteristics and clinical outcomes of adults and children with anti-MDA-5 antibody-associated myositis: a prospective observational bicentric study. Rheumatol Int. 2021. doi: 10.1007/s00296-021-04897-1. Epub ahead of print. PMID: 34050793.  Back to cited text no. 4
    


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