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Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile
Kothapalli Nagamounika1, Josna Joseph1, R Hemanth Kumar2, John Mathew1
1 Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India
Correspondence Address:
John Mathew,
Department Clinical Immunology and Rheumatology, Prince Manor Bldng, Christian Medical College, Vellore - 632 006, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/injr.injr_82_22
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Statin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker. In this context, this case, which is the first one reported from a tertiary care center in South India, is unique. The presence of hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody supplements the clinical diagnosis, specifically in the serological absence of myositis-specific antibodies. A comprehensive diagnostic approach including HMGCR antibody positivity is advisable in IMNM.
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