Tab Application Banner
  • Users Online: 718
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Impact of COVID-19 on rheumatic diseases in india: Determinants of mortality and adverse outcome: A retrospective, cross-sectional cohort study


1 Department of Clinical Immunology & Rheumatology, SMS Medical College & Hospital, Jaipur, India
2 Department of Clinical Immunology & Rheumatology, St John's Medical College Hospital, Bangalore, India
3 ChanRe Rheumatology and Immunology Center and Research, Bangalore, India
4 Center for Arthritis and Rheumatism excellence, Kochi, Kerala, India
5 Division of Clinical Immunology & Rheumatology, Smt. NHL Municipal Med college and SVP hospital, Ahmedabad, India
6 Optima Arthritis & Rheumatology Clinic, Bangalore, India
7 Department of Clinical Immunology & Rheumatology, Medanta Super Speciality Hospital, Indore, India
8 Department of Clinical Immunology & Rheumatology, Manipal Hospital, Bangalore, India
9 Department of Clinical Immunology & Rheumatology, Dayanand Medical College & Hospital, Ludhiana, India
10 STAR Rheumatology Clinics and SVP Hospital, Ahmedabad, Gujarat, India
11 Citi Neuro Centre, Hyderabad, Telangana, India
12 Department of Medicine, SMS Medical College & Hospital, Jaipur, India
13 Omkar Rheumatology Clinic, Ahmedabad, India
14 Department of Clinical Immunology & Rheumatology, Subodaya Rheumatology Hospital, Ahmedabad, India
15 Apollo Hospital, Ahmedabad, India
16 Rheumatology Clinic, Ahmedabad, India
17 Department of Clinical Immunology & Rheumatology, Yashoda hospitals, Malakpet, Hyderabad, Telangana, India
18 Department of Clinical Immunology & Rheumatology, Amala institute of medical Sciences, Thrissur, India
19 Arthritis and Rheumatology Centre, Indore, India
20 Fortis Escorts Hospital, Jaipur, India

Correspondence Address:
Vineeta Shobha,
Department of Clinical Immunology and Rheumatology, St John's Medical College Hospital, Sarjapur Road, Bengaluru - 560 034, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_278_21

Introduction: There is varying impact of COVID19 on world population depending on ethnicity, age and underlying co-morbidities. However, the lack of data regarding the effect of COVID on patients with rheumatological disorders (RDs) from different nations adds to uncertainty on disease outcome. Across the world, many rheumatology associations have joined hands to collate-related information. A national database under Indian Rheumatology Associations (IRAs) was developed to understand the impact of underlying RD and immunosuppressants during the COVID pandemic on its severity and outcome in our country. Methods: All registered members of IRA were invited to participate in this registry and provide information of reverse transcription–polymerase chain reaction confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infected RD patients using an online platform https://iradatabaseard.in/iracovid/index.php. The results of the data were analyzed using the appropriate statistics. Multivariate logistic regression was used to analyze the impact of different variables on mortality. Odds ratio and 95% confidence interval were used to define risk of death. Results: In this retrospective cross-sectional study, data for 447 RD patients who were infected with SARS-CoV2 data were available as of December 1, 2020. The mean age was 47.9 ± 14.4 years, including two children and 93 (20.8%) geriatric age group patients, male: female ratio was 0.4:1 and mean disease duration was 79.3 ± 77.1 months. Rheumatoid arthritis was the most common RD. Underlying disease was quiescent in 54.7% and active in 18.4% patients. Most common medications at the time of COVID diagnosis were steroids (57.76%) and hydroxychloroquine (67.34%). Fever and cough were the most common symptoms. More than half of the patients (54.4%) needed hospitalization. Oxygen requirement was noted in 18.8%, intensive care unit admission, and invasive ventilation was needed in 6.0%, and 2.9% patients, respectively. Complete recovery was seen in 95.5% of patients and 4.47% (n = 20) expired due to COVID. The presence of comorbidity, dyspnea, and a higher neutrophil count was statistically significantly associated with death (P < 0.05). None of the other factors affected COVID-19 outcome. Conclusion: This is the largest cohort from a single nation looking at the interface between RD and COVID. The results indicate that patients with RD do not show increased mortality despite current use of disease-modifying anti-rheumatic drugs/immunosuppressants.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Jain A
    -  Shobha V
    -  Chandrashekara S
    -  Shenoy P
    -  Pandya SC
    -  Chotalia P
    -  Kumar S
    -  Malviya S
    -  Singh YP
    -  Patil A
    -  Gupta V
    -  Srivastava P
    -  Parimi VP
    -  Kodishala C
    -  Janardana R
    -  Pinto B
    -  Bhandari S
    -  Rankawat G
    -  Jadhav PP
    -  Potugari D
    -  Sharma V
    -  Parmar A
    -  Kayidhi S
    -  Antony PT
    -  Badika A
    -  Sharma A
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed185    
    PDF Downloaded5    

Recommend this journal