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ORIGINAL ARTICLE
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Clinical profiling of psoriatic arthritis: an observational cross-sectional study from Karnataka Psoriatic Arthritis Cohort


1 St. John's Medical College Hospital, Bengaluru, Karnataka, India
2 ChanRe Rheumatology and Immunology Research Centre, Bengaluru, Karnataka, India
3 Columbia Asia Hospital, Bengaluru, Karnataka, India
4 Arthritis Specialty Clinic, Hubli, Karnataka, India
5 Manipal Hospitals, Bengaluru, Karnataka, India
6 Vikram Hospital, Bengaluru, Karnataka, India
7 Narayana Health City, Bengaluru, Karnataka, India
8 Sakra Hospital, Bengaluru, Karnataka, India
9 SDM Medical College, Dharwad, Karnataka, India
10 JSS Medical College, Mysore, Karnataka, India
11 Yenepoya Specialty Hospital, Mangalore, Karnataka, India
12 Apollo Hospital, Bengaluru, Karnataka, India
13 Mahaveer Jain Hospital, Bengaluru, Karnataka, India
14 Aster CMI Hospital, Bengaluru, Karnataka, India
15 Apollo BGS Hospital, Mysore, Karnataka, India
16 Fortis Hospital, Bengaluru, Karnataka, India
17 Sparsh Hospital, Bengaluru, Karnataka, India
18 Samarpan Health Centre, Bengaluru, Karnataka, India

Correspondence Address:
Vineeta Shobha,
Department of Clinical Immunology and Rheumatology, St John's Medical College Hospital, Sarjapur Road, Bengaluru - 560 034, Karnataka
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_213_21

Background: Clinical patterns and disease activity burden of psoriatic arthritis (PsA) varies in different parts of the world. There are limited studies from the Indian subcontinent. Aims: To study the cutaneous and articular profile of PsA and describe their disease activity with validated outcome measures. Methods: Karnataka psoriatic arthritis cohort study is a multicenter, prospective, cross-sectional, observational study which included all consecutive PsA patients defined by Classification criteria for psoriatic arthritis (CASPAR) from 18 rheumatology centers. Results: A total of 549 PsA patients (M: F: 6:5), mean age 38.4 (±14) years were included. PsA preceded psoriasis in 81 (14.7%) while simultaneous onset was noted in 117 (21.5%). Plaque lesions (330 [78.8%]) and scalp (210 [49.2%]) were the most common type and site. Mild, moderate, and severe skin disease was noted in 480 (80%), 50 (9.3%), and 57 (10.6%) patients, respectively. Mean disease activity in PsA (DAPSA) was 18.8 (16.6); 100 (19.9%) were in remission. Low, moderate, and high joint disease activity was found in 145 (28.8%), 137 (27.2%), and 123 (24.5%), respectively. There was no correlation between skin and joint disease. Polyarthritis (216 [40.7%]) and oligoarthritis (202 [38.1%]) were the most frequent PsA subtypes. Those with a higher DAPSA (>28) were older (P = 0.02), had a shorter duration of psoriasis (P = 0.02) and higher psoriatic area and severity index scores (P = 0.0001). Conclusions: We report high articular disease activity in half while cutaneous disease activity was minimal in majority.


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