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Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy

1 Department of Neurology, Bangur Institute of Neuroscience, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
2 Department of Internal Medicine, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India

Correspondence Address:
Amlan Kusum Datta,
Bangur Institute of Neurosciences, 52 1/A Sambhu Nath Pandit Road, Bhowanipore, Kolkata - 700 020, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_295_20

Spondyloarthropathies (SpA) are a group of overlapping disorders sharing certain common clinical features and genetic associations. Historically, most of the research into the pathogenesis of SpA and other types of chronic arthritis have conventionally focused on the adaptive immune system. However, recently, the pendulum has shifted in favor of innate immunity. With an aim to explore bridging concept of major histocompatibility locus (MHC)-I-opathy in context of immunopathogenesis of SpA, MEDLINE and PubMed (2000-2019) databases were searched for English language articles using keywords “MHC-I-opathy” and “spondyloarthropathy.” We reviewed papers which addressed the concept of overlap between innate and adaptive immunity and interplay between local tissue factors and innate cellular responses in the pathogenesis of SpA. The term “MHC-I-opathy” encompasses of a group of diseases which exhibit interaction between tissue-specific factors and innate immune cells. Further studies are needed for understanding of its therapeutic implication in such diseases.

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