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Year : 2022  |  Volume : 17  |  Issue : 3  |  Page : 289-293

Intrauterine onset of multisystem inflammatory syndrome in a neonate temporally associated with maternal COVID-19

1 Department of Paediatrics, Amala Institute of Medical Sciences, Thrissur, Kerala, India
2 Department of Cardiology, Amala Institute of Medical Sciences, Thrissur, Kerala, India

Correspondence Address:
Dr. Shiji Joseph
Department of Paediatrics, Amala Institute of Medical Sciences, Amala Nagar, Thrissur - 680 555, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_4_22

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Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a rare but often life-threatening clinical entity that presents 3–6 weeks after SARS-CoV-2 infection with high fever, organ dysfunction, and strongly elevated markers of inflammation. Unlike MIS-C, where SARS-CoV-2 infection and multisystem inflammation occur in the same subject, maternal SARS-CoV-2 infection may cause a similar hyperinflammatory syndrome in neonates called multisystem inflammatory syndrome in neonates (MIS-N) due to transplacental transfer of antibodies. The clinical profile of these babies remains obscure due to a lack of published literature. Our case highlights the need for practicing pediatricians to be vigilant and to have a high index of clinical suspicion of MIS-N in all critically ill neonates irrespective of antenatal COVID-19 status of mother.

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