Tab Application Banner
  • Users Online: 198
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2021  |  Volume : 16  |  Issue : 5  |  Page : 29-38

Genetics and pathogenesis of connective tissue disease-associated interstitial lung disease


OPTIMA Arthritis and Rheumatology Clinics, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Sharath Kumar
185, 1st Main Road, Mahalaxmi Layout, Behind Mahalaxmi Metro Station, Next to Abaran Showroom, Bengaluru - 560 086, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-3698.332976

Rights and Permissions

Connective tissue diseases (CTD) are a broad category of diseases with autoimmune etiology and multi-system involvement. The lung seems to be involved in some form in most CTDs. Interstitial lung disease (ILD) is the prototypic lung manifestation and is seen in 2%–50% of patients with CTDs.[1] It leads to significant morbidity and mortality. Unfortunately, the ubiquitous involvement across CTDs, along with the possible benefit of treating this manifestation, has not translated into a good understanding of its pathogenesis or treatment. We must aim for a better understanding of the genetic determinants of this manifestation (to help identify those who are at risk) as well as its pathogenesis (to help identify therapeutic targets). This review aims to provide a summary of the key genetic determinants of CTD-ILD as well as the key players of the pathogenic pathway of this manifestation.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed352    
    Printed10    
    Emailed0    
    PDF Downloaded69    
    Comments [Add]    

Recommend this journal