| REVIEW ARTICLE |
|
| Year : 2020 | Volume
: 15
| Issue : 5 | Page : 6-12 |
|
|
Current concepts in the pathogenesis of spondyloarthritis
Nibha Jain, Arumugam Moorthy
University Hospitals of Leicester NHS Trust, Leicester, UK
Correspondence Address:
Dr. Arumugam Moorthy
Consultant Rheumatologist, University Hospitals of Leicester NHS Trust, Leicester
UK
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-3698.284745
|
|
|
Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environmental factors including gut dysbiosis, mechanical stress, and transduction have been implicated in the pathogenesis. Recently, the interleukin (IL)-17/IL-23 pathway has been major focus due to it being therapeutic target. Herein, we reviewed various recent developments and current concepts in the pathogenesis of SpA.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
