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Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 121-124

Correlation of QT interval with disease activity in newly detected SLE patients at baseline and during flare

1 Global Hospitals; Department of Rheumatology, Madras Medical College, Chennai, India
2 Department of Rheumatology, Madras Medical College, Chennai, India

Correspondence Address:
Santhanam Sham
Global Hospitals; Department of Rheumatology, Madras Medical College, Chennai
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Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.injr.2015.03.010

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Aim: To study correlation between QT interval parameters (QTc interval & QT dispersion) and disease activity (SLEDAI) in patients with systemic lupus erythematosus (SLE). Methods: The study was done on 100 newly diagnosed patients with SLE and 100 age matched controls from January 2012 to December 2013. A standard 12 lead Electrocardio- gram was obtained. QT interval was calculated from beginning of 'q' wave to end of T wave in lead II or lateral leads (V5, V6). QT dispersion was measured as the difference between maximum and minimum QT intervals. SLE disease activity was measured SLEDAI. Results: Eighty four patients had high disease activity. QTc was > 440 msec in 51 patients and 6 controls. QTd was prolonged in 6 patients and 6 controls. The mean QTc interval among patients (463.30 ± 27.43 msec) was higher than in controls (397.24 ± 31.85 msec; p < 0.001). However the mean QTd among patients (44.40 + 20.61 msec) was similar to that in controls (39.2 + 17.7 msec). Difference of QTc values during severe flare from baseline QTc values was statistically significant (r = 0.863; Pearson's correlation coefficient). Conclusions: Patients with high disease activity have higher prevalence of QTc prolongation, QTc interval may be used as a surrogate marker for assessing disease activity in SLE.

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