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ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 2  |  Page : 53-57

Increased prevalence of subclinical atherosclerosis in ankylosing spondylitis


1 Department of Medicine, All India Institute of Medical Sciences, New Delhi; Department of Internal Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India
2 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Shefali K Sharma
Department of Medicine, All India Institute of Medical Sciences, New Delhi; Department of Internal Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2015.02.002

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Objectives: The increased risk of atherosclerosis in inflammatory rheumatic diseases like rheumatoid arthritis and systemic lupus erythematosus has been established in various studies. However, similar studies in ankylosing spondylitis (AS) have yielded conflicting results. We studied subclinical atherosclerosis and endothelial dysfunction sono- graphically in AS patients and compared the results with matched healthy controls. Methods: Fifty AS patients and 50 age and sex matched controls were recruited. However, 45 AS patients (28.6 ± 8.2 years; 42 males and 3 females) and 42 healthy controls (29.6 ± 8.6 years; 38 males and 4 females) were studied, as the others were excluded because of dyslipidemia. Height, weight, and waist circumference measurements were taken. Flow- mediated dilatation (FMD) of the brachial artery, intima-media thickness of the common carotid artery (CIMT) and ankle-brachial index (ABI) were measured sonographically. Results: AS patients had significantly higher CIMT compared to controls (0.56 ± 0.1 mm in AS patients and 0.51 ± 0.08 mm in controls; p = 0.03). FMD was lower in AS patients (14.1 ± 9.7%) as compared to controls (18.1 ± 8.7%; p = 0.04) and ABI was higher in patients (1.16 ± 0.1) as compared to controls (1.1 ± 0.1; p = 0.05) 20% of AS cases had impaired FMD (defined as a FMD <4.5%) compared to none among the controls (p = 0.03). Conclusions: This study revealed an increased prevalence of subclinical atherosclerosis in AS patients.


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