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Year : 2014  |  Volume : 9  |  Issue : 1  |  Page : 9-13

Lipid profile and its relationship with endothelial dysfunction and disease activity in patients of early Rheumatoid Arthritis

1 Department of Medicine, Rheumatology Division, Calcutta Medical College, Kolkata, India
2 Department of Preventive and Social Medicine, All India Institute of Hygiene and Public Health, Kolkata, India
3 Department of Microbiology, GSL Medical College, Rajahmundry, AP, India

Correspondence Address:
Rathindra Nath Sarkar
Department of Medicine, Rheumatology Division, Calcutta Medical College, Kolkata
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Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.injr.2014.01.003

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Background: Lipid profile derangements in patients with early rheumatoid arthritis (RA) have been described. These may predispose to premature atherosclerosis and early car- diovascular events. However data from India is sparse. Objective: To evaluate the serum lipid profiles in patients of early RA, and assess the inter- relationship between serum lipid profile, endothelial dysfunction, disease activity and inflammatory markers. Materials and Methods: 50 patients of early RA and 50 age and sex matched healthy controls were included in the study. Fasting lipid profiles and brachial artery flow mediated vaso- dilatation (FMV%) were estimated, along with other disease activity parameters in the RA group. Result: Early RA patients showed an atherogenic lipid profile characterized by an increase in the Total Cholesterol (TC) (180.12 ± 16.50 versus 141.30 ± 9.57; p value < 0.0001) and Low Density Lipoprotein-Cholesterol (LDL-C) (126.82 ± 17.49 versus 79.36 ± 10.04; p value < 0.0001) and a reduction in the High Density Lipoprotein-Cholesterol (HDL-C) (37.92 ± 3.85 versus 44.42 ± 4.38; p value < 0.0001) as compared with their age and sex matched healthy controls. Mean FMV% in early RA patients (3.87 ± 1.70) was less than the controls (8.7 ± 1.58). Patients of early RA showed an atherogenic lipid profile with high atherogenic ratios of TC/HDL and LDL/HDL thus suggesting that these patients are at higher risk of developing atherosclerosis. There was significant correlation between lipo- protein levels, disease activity, endothelial dysfunction and inflammation. Conclusion: Patients of early rheumatoid arthritis have an atherogenic lipid profile and impaired FMV%, which correlates with disease activity and inflammation.

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