Tab Application Banner
  • Users Online: 1191
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2013  |  Volume : 8  |  Issue : 4  |  Page : 165-169

Evaluation of efficacy of fluoxetine in the management of major depression and arthritis in patients of Rheumatoid Arthritis

1 Department of Psychiatry, ESIC Model Hospital, Ajmer Road, Jaipur, Rajasthan, India
2 Department of Nephrology, SGPGI, Lucknow, UP, India

Correspondence Address:
Akhilesh Jain
Department of Psychiatry, ESIC Model Hospital, Ajmer Road, Jaipur, Rajasthan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.injr.2013.08.001

Rights and Permissions

Background: Patients with chronic pain suffer significant reduction in physical, psycho- logical, and social well-being. Anxiety and depressive disorders occur in 20%e25% of pa- tients with Rheumatoid Arthritis (RA). Antidepressants are useful in the treatment of major depression, however the analgesic properties of this class of drugs is not clear. Objective: To study the association between RA and depression along with independent effect of fluoxetine on depression and arthritis. Method: One hundred women attending a rheumatology clinic with RA were included in the study along with controls. Hospital Anxiety Depression Rating Scale (HADS), Montgomerye Asberg Depression Rating Scale (MADRS) and Clinical Global Impression - Change Scale (CGI) were applied. Both the groups were treated with DMARD. RA with depression group also received fluoxetine. Results: Depression is significantly associated with RA; however severity of RA has no relationship with severity of depression. Treatment outcome was better and earlier with add on fluoxetine in the RA with depression group as compared to RA without depression. Conclusion: Treatment of associated depression may expedite the recovery of physical symptoms thus improving the quality of life of an individual with chronic painful conditions.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded172    
    Comments [Add]    
    Cited by others 4    

Recommend this journal