Tab Application Banner
  • Users Online: 520
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2008  |  Volume : 3  |  Issue : 4  |  Page : 158-166

Rheumatic manifestations of HCV infection

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Correspondence Address:
V Agarwal
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Hepatitis C virus (HCV) is the major cause of post transfusion viral hepatitis and affects > 180 million people world wide. Besides being hepatotropic, HCV is lymphotropic as well and predominantly affects the B cells leading to non- neoplastic clonal proliferation with potential to induce B-cell malignancies. Rheumatic manifestations are being increasingly recognized and appreciated as part of spectrum of chronic HCV infection. Mixed cryoglobulinemia (MC) is the most common and prototype disorder induced. Besides MC, sicca syndrome, HCV associated arthritis, systemic vasculitis, cytopenias, fatigue and fibromyalgia have been documented. Moreover, chronic HCV infection induces a number of autoantibodies and may mimic various autoimmune disorders. Recognition and distinction of these features may help in choosing correct therapeutic approach as immunosuppressive therapy may be detrimental in HCV infection. Antiviral regimen, ribavirin and interferon-α, remains the cornerstone for the treatment of MC, however other rheu- matic manifestations may not respond similarly. There is a great need for better understanding of the pathophysiology of these manifestations.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded109    
    Comments [Add]    

Recommend this journal